By Little Pro on 2016-08-11 Views: Update:2017-03-31
This is the answer to the quiz on how to modify dose descriptors to a correct starting point. The original quiz and tutorial can be accessed here.
Q1: Is modification of dose descriptor necessary if using oral NOAEL (rat) to derive DNELs for oral route for general population?
Explanation: Modification of dose descriptors is only necessary if there are bioavailablity differences(absorption) between animals and humans, differences in exposure units (e.g, mg/kg bw/d or mg/m3), differences in exposure conditions between animals and humans and differences in respiratory volume (for inhlation route only).
Q2: Is modification of dose descriptor necessary if using inhalatory NOAEC (rat) to derive DNELs for inhalation route for workers and general population?
Explanation: Exposure conditions are different between rats and humans. (6h/d for rat, 8h/d for workers and 24h/d for general population).
Q3: What is corrected dose descriptor (NOAEL) for deriving DNELs for oral route for humans based on the the following data?
Answer: 10mg/kg bw/day